Nano Letters | Team Develops New Drug Delivery System for Wound and Muscle Inflammation

Researchers from our university have developed a novel hydrogel-based drug delivery system (PON-G) for treating superficial wounds and skeletal muscle inflammation. The study, published in Nano Letters, demonstrates that the system uses sequential photodynamic therapy to detect bacteria and adjust treatment dynamically.

Tests on pig, rabbit, and mouse models showed PON-G effectively reduces inflammation and promotes muscle regeneration. Single‑nucleus RNA sequencing revealed that the treatment shifts cells from an immune‑infiltrating state to a tissue‑remodeling state, increasing mature muscle fibers and improving healing.

The first author of the paper is Associate Professor Li Haohuan from the College of Veterinary Medicine at our university. Graduate students Xie Hailong and Zhang Jiaman are co-first authors. Associate Professor Li Haohuan and Professor Li Mingzhou from the College of Animal Science and Technology are the corresponding authors.

Paper information:    https://pubs.acs.org/articlesonrequest/AOR-Q4KR5R3JFM84QYF8SJJR