Zhengli Chen

Identity

   · Vice Dean

   · Professor

   · Executive Director,Chinese Society of Animal Anatomy and Histoembryology

   · Chairman, Faculty Representative Committee, College of Veterinary Medicine 

Education

   · 09/2001-07/2004, PhD in Clinical Veterinary Medicine, Northwest Agriculture & Forestry University

   · 09/1998-07/2001, M.S. in Basic Veterinary Medicine, Northwest Agriculture & Forestry University

   · 09/1994-07/1998, B.S. in Animal Husbandry and Veterinary, Sichuan Animal Husbandry and Veterinary College

Training and Professional Experience

   · 2012-now, Professor, College of veterinary medicine, Sichuan Agricultural University

   · 2007, Associate Professor, College of veterinary medicine, Sichuan Agricultural University

   ·2004, Lecturer, College of veterinary medicine, Sichuan Agricultural University

Research Interests

   · Focus on the Establishment of experimental animal disease model, Animal pathology, Evaluation of drug toxicity and drug screening.

Selected Publications 

   · Yu Xia, Qihui Luo, Jingfei Chen, Chao Huang, Asad Jahangir, Ting Pan, Xiaoli Wei, Wentao Liu & Zhengli Chen. Retinal Astrocytes and Microglia Activation in Diabetic Retinopathy Rhesus Monkey Models. Curr Eye Res. 2022;47(2):297-303. DOI:10.1080/02713683.2021.1984535

   · Chao Huang, Huan Gong, Bin Mu, Xinting Lan, Chengcheng Yang, Jinlong Tan, Wentao Liu, Yuanfeng Zou, Lixia Li, Bin Feng, Xia He, Qihui Luo and Zhengli Chen. BAF-L Modulates Histone-to-Protamine Transition during Spermiogenesis [J]. Int J Mol Sci. 2022;23(4):1985. Published 2022 Feb 11. DOI:10.3390/ijms23041985

   · Chao Huang, Chengcheng Yang, Dejiang Pang, Chao Li, Huan Gong, Xiyue Cao, Xia He, Xueyao Chen, Bin Mu, Yiyuan Cui, Wentao Liu, Qihui Luo, Anchun Cheng, Lanlan Jia, Mina Chen, Bo Xiao and Zhengli Chen. Animal models of male subfertility targeted on LanCL1-regulated spermatogenic redox homeostasis. Lab Anim (NY). 2022;51(5):133-145. DOI:10.1038/s41684-022-00961-w（封面文章）

   · Chao Huang, Xiaoli Wei, Qihui Luo, Yu Xia, Ting Pan, Junbo He, Asad Jahangir, Lanlan Jia, Wentao Liu, Yuanfeng Zou, Lixia Li, Hongrui Guo, Yi Geng and Zhengli Chen. Loss of TRIM67 Attenuates the Progress of Obesity-Induced Non-Alcoholic Fatty Liver Disease [J]. Int J Mol Sci. 2022;23(13):7475. Published 2022 Jul 5. DOI:10.3390/ijms23137475

   ·Qihui Luo, Asad Jahangir, Junbo He, Chao Huang, Yu Xia, Lanlan Jia, Xiaoli Wei, Ting Pan, Yanni Du, Bin Mu, Huan Gong, Wentao Liu, Saif Ur-Rehman , Kangcheng Pan and Zhengli Chen. Ameliorating Effects of TRIM67 against Intestinal Inflammation and Barrier Dysfunction Induced by High Fat Diet in Obese Mice. Int J Mol Sci. 2022;23(14):7650. Published 2022 Jul 11. DOI:10.3390/ijms23147650

   · Qihui Luo, Lanlan Jia, Chao Huang, Qi Qi, Asad Jahangir, Yu Xia, Wentao Liu, Riyi Shi, Li Tang and Zhengli Chen. Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway. Int J Mol Sci. 2022;23(16):9368. Published 2022 Aug 19. DOI:10.3390/ijms23169368

   ·Lanlan Jia, Zhengli Chen, Ting Pan, Yu Xia, Junbo He, Asad Jahangir, Xiaoli Wei ,Wentao Liu, Riyi Shi, Chao Huang and Qihui Luo. TRIM67 Deficiency Exacerbates Hypothalamic Inflammation and Fat Accumulation in Obese Mice [J]. Int J Mol Sci. 2022;23(16):9438. Published 2022 Aug 21. DOI:10.3390/ijms23169438

   ·Liangqin Shi, Yazhou Lin, Yucheng Jiao, Seth A. Herr, Jonathan Tang, Edmond Rogers, Zhengli Chen, Riyi Shi. Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson’s disease: implication of acrolein and TRPA1. Translational Neurodegeneration , 2021 ,10:13.

   · QihuiLuo, XinyuLei, JingXu,AsadJahangir, JunboHe, ChaoHuang, WentaoLiu, AnchunCheng, LiTang,YiGeng, ZhengliChen. An altered gut microbiota in duck-origin parvovirus infection on cherry valley ducklings is associated with mucosal barrier. Poultry Science, 2021, 100(4):101021.

 ·Qihui Luo, Chengjie Lao, Chao Huang, Yu Xia, Wenjing Ma, Wentao Liu, Zhengli Chen. Iron Overload Resulting from the Chronic Oral Administration of Ferric Citrate Impairs Intestinal Immune and Barrier in Mice. Biological Trace Element Research, 2021, 199:1027–1036.

   · Liangqin Shi, Chao Huang, Qihui Luo, Yu Xia, Wentao Liu, Wen Zeng, Anchun Cheng, Riyi Shi, Chen Zhengli.Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT mTOR pathway. Aging-US, 2020,12(10):9515-9533.

   · Liangqin Shi, Chao Huang, Qihui Luo, Edmond Rogers, Yu Xia, Wentao Liu, Wenjing Ma,Wen Zeng, Li Gong, Jing Fang, Li Tang, Anchun Cheng, Riyi Shi, Zheng-li Chen.The association of iron and the pathologies of Parkinson’s diseases in MPTP/MPP+-induced neuronal degeneration in non-human primates and in cell culture. Frontiers in Aging Neuroscience,2019,11:215.

   · Chao Huang, Wenjing Ma, Qihui Luo, Liangqin Shi, Yu Xia, Chengjie Lao, Wentao Liu, Yuanfeng Zou, Anchun Cheng, Riyi Shi, Zhengli Chen. Iron overload resulting from the chronic oral administration of ferric citrate induces parkinsonism phenotypes in middle-aged mice. Aging-US,2019,11.

   · Dejiang Pang, Chao Li, Chengcheng Yang, Yuanfeng Zou, Bin Feng, Lixia Li, Wentao Liu, Yi Geng, Qihui Luo, Zhengli Chen, Chao Huang. Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide. Oxidative Medicine and Cellular Longevity, 2019, https://doi.org/10.1155/2019/1805635

   · Qihui Luo, Yifan Li, Chao Huang, Dongjing Cheng, Wenjing Ma, Yu Xia, Wentao Liu and Zhengli Chen. Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway. Molecules,2019,24:2966

   · Jinlong Tan, Chao Huang, Qihui Luo, Wentao Liu, Dongjing Cheng, Yifan Li, Yu Xia, Chao Li, Li Tang, Jing Fang, Kangcheng Pan, Yangping Ou, Anchun Cheng and Zhengli Chen. Soy Isoflavones Ameliorate Fatty Acid Metabolism  of Visceral Adipose Tissue by Increasing  the AMPK Activity in Male Rats with  Diet-Induced Obesity (DIO). Molecules,2019,24:2809

   · Qihui Luo, Jing Xu, Chao Huang, Xinyu Lei, Dongjing Cheng, Wentao Liu, Anchun Cheng, Li Tang, Jing Fang, Yangping Ou, Yi Geng and Zhengli Chen. Impacts of Duck-Origin Parvovirus Infection on Cherry Valley Ducklings From the Perspective of Gut Microbiota. Front. Microbiol.,2019,10:624

   · Qihui Luo, Dongjing Cheng, Chao Huang,Yifan Li, Chengjie Lao, Yu Xia, Wentao Liu, Xiaoxia Gong, Danlei Hu, Bin Li, Xue He and Zhengli Chen. Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats. Molecules,2019,24:1139

   · Jingfei Chen, Qihui Luo, Chao Huang, Wen Zeng, Ping Chen, Qi Gao, Bing Chen, Wentao Liu, Lingzhen Pan, and Zhengli Chen.Morphology of Inner Retina in Rhesus Monkeys of Various Ages: A Comparative Study.Journal of Ophthalmology,2019,7, https://doi.org/10.1155/2019/7089342.

   · Qihui Luo, Bing Chen, Jing Xu, Wenjing Ma, Chengjie Lao, Yifan Li, Jinglong Tan, Yi Tang, Chao Huang, Wentao Liu, Zhengli Chen. Development of a SYBR Green II Real-Time Polymerase Chain Reaction for the Clinical Detection of the Duck-Origin Goose Parvovirus in China.Intervirology,2018, DOI: 10.1159/000495181.

   · Qihui Luo, Dandan Yang, Qi Qi, Chao Huang, Bing Chen, Wentao Liu, Liangqin Shi, Yu Xia, Li Tang, Jing Fang, Yangping Ou, Yi Geng, and Zhengli Chen. Role of the Death Receptor and Endoplasmic Reticulum Stress Signaling Pathways in Polyphyllin I-Regulated Apoptosis of Human Hepatocellular Carcinoma HepG2 Cells. BioMed Research International,2018,https://doi.org/10.1155/2018/5241941.

   · Qi Gao, Chengdong Wang, Desheng Li, Hemin Zhang, Linhua Deng, Caiwu Li and Zhengli Chen. A case of giant panda ovarian cancer diagnosis and histopathology. BMC Veterinary Research,2018,14:311.

   · Qihui Luo, Shanshan Chen, Juan Deng, Liangqin Shi, Chao Huang, Anchun Cheng, Wentao Liu, Jing Fang, Li Tang, Yi Geng, Zhengli Chen.Endocannabinoid hydrolase and cannabinoid receptor 1 are involved in the regulation of hypothalamus-pituitary-adrenal axis in type 2 diabetes. Metabolic Brain Disease,2018,33:1483–1492

   · Ping Chen, Qihui Luo, Chao Huang, Qi Gao, Like Li, Jingfei Chen, Bing Chen, Wentao Liu, Wen Zeng, Zhengli Chen. Pathogenesis of non-alcoholic fatty liver disease mediated by YAP. Hepatology International (2018) 12:26–36

   · Liangqin Shi, Chao Huang, Qihui Luo, Yu Xia, Heng Liu, Like Li, Wentao Liu, Wenjing Ma,Jing Fang, Li Tang, Wen Zeng, Zhengli Chen. Pilot study: Molecular risk factors fordiagnosing sporadic Parkinson’s disease based on gene expression in blood in MPTP-induced rhesus monkeys. Oncotarget[J],2017,8(62),105606-105614.

   · Like Li, Xiaolin Chen, Qihui Luo, Chao Huang, Wentao Liu, Zhengli Chen. Effects of soy isoflavones on testosterone synthetase in diet-induced obesity male rats. Int J Clin Exp Pathol 2017;10(9):9202-9212

   · Jing Hua, Xiyue Cao, Dejiang Pang, Qihui Luo, Yuanfeng Zou, Bin Feng, Lixia Li, Zhengli Chen, Chao Huang. Tumor grade related expression of neuroglobin is negatively regulated by PPARγ and confers antioxidant activity in glioma progression. Redox Biology,2017,12:682

   · Like Li, Liangqin Shi,Heng Liu, QihuiLuo, ChaoHuang,WentaoLiu,Xiaolin Chen,Wen Zeng, Zhengli Chen. Changes in blood anti-oxidation enzyme levels in MPTP-treated monkeys. Neuroscience letters,2017 ,649(10):93-99

   · Qi-Hui Luo, Meng-Lu Chen, Zheng-Li Chen, Chao Huang, An-Chun Cheng, Jing Fang, Li Tang, Yi Geng. Evaluation of KIM-1 and NGAL as Early Indicators for Assessment of Gentamycin- Induced Nephrotoxicity In Vivo and In Vitro. Kidney Blood Press Res, 2016;41:911-918

   · Chao Huang, Dejiang Pang, Qihui Luo, Xiaolin Chen, Qi Gao, Liangqin Shi, Wentao Liu, Yuanfeng Zou, Lixia Li and Zhengli Chen. Soy Isoflavones Regulate Lipid Metabolism through an AKT/mTORC1 Pathway in Diet-Induced Obesity (DIO) Male Rats. Molecules, 2016, 21:586

   · Qihui Luo, Zhengli Chen, Anchun Cheng, Mingshu Wang, Jing Fang, Xi Peng, Li Tang. Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats. Front. Med. 2015, 9(1): 82–89

   · Qi-hui Luo, Meng-lu Chen, Feng-jiao Sun, Zheng-li Chen, Ming-yang Li, Wen Zeng, Li Gong, An-chun Cheng, Xi Peng, Jing Fang, Li Tang, Yi Geng. KIM-1 and NGAL as biomarkers of nephrotoxicity induced by gentamicin in rats. Mol Cell Biochem,2014,397:53–60

   · Qihui Luo, Wentao Liu, Jingyao Chen, Mingshu Wang, Wen Zeng, Zhengli Chen, Anchun Cheng. Nerve growth factor and inducible nitric oxide synthase expression in the mesencephalon and diencephalon, as well as visual- and auditory-related nervous tissues, in a macaque model of type 2 diabetes. Neural Regeneration Research,2012,7(4):302-307.

   · Zheng-li CHEN, Wen ZENG, An-chun CHENG, Qi-hui LUO, Zhan LI, Xi PENG, Jing FANG, Kang-cheng PAN, Min HE, Li TANG. Six-month repeated dose toxicity of orally administered metacavir in rhesus monkeys. Experimental and Toxicologic Pathology,2011, 63(4):379-385.

   · Shasha Zhou, Qihui Luo, Zhengli Chen, Anchun Cheng, Mingshu Wang, Dekang Zhu, Renyong Jia, Fei Liu, Xiaoyue Chen,Yi Zhou, Fengjun Bi, Zexia Yang. Isolation, identification of Streptococcus pneumoniae from infected rhesus monkeys and control efficacy. Journal of Medical Primatology,2010,39: 417-423.

   · Chen Zheng-li,Zhu Chun-mei,Luo Qi-hui,Pan Kang-cheng. Expression of estrogen receptor alpha, nerve growth factor, interleukin-2, and androgen receptor in the cerebellum of ovariectomized rats following soybean isoflavone treatment.Neural Regeneration Research，2009,4(12):965-972.

   · Zeng Wen,Cheng An-chun, Chen Zheng-li, Luo Qi-hui,Sun Yu-bo, Li Zhan,Bi Feng-jun. In Vivo Assessment of Mitochondrial Toxicity of Metacavir in Rhesus Monkeys after Three Months of Intravenous Administration. Acta Pharmacologica Sinica,2009,30(12):1666-1673.

   · CHEN Zheng-li, FAN Guang-li, LUOQi-hui, ZHUChun-mei, HUANGYi-dan. Effects of Estrogen on ER, NGF, and ChAT Expression in Cerebellum of Aging Female Sprague-Dawley Rat. Agricultural Sciences in China, 2007, 6(3): 368-374.