Chao Huang

Identity

 ·  Professor     

Education

 ·  09/2009-06/2014, PhD. in Cell Biology, Sichuan University

 ·  09/2005-06/2009, B.S. in Biotechnology, Sichuan University

Training and Professional Experience

 ·  2021-now, Professor, Sichuan Agricultural University College of Veterinary Medicine

 ·   2017-2021, Associate Professor, Sichuan Agricultural University College of Veterinary Medicine

 ·  2015-2017, Lecturer, Sichuan Agricultural University College of Veterinary Medicine

Research Interests

 ·  We focus on the identification of key genes in the developmental process of the mouse brain and testis and their functional studies, especially the genes and signal pathways that maintain the balance of cellular redox homeostasis and promote the cellular proliferation, differentiation and survival during development. On this basis, we establish the experimental animal models of neurodegenerative disorders and male infertility through genetically modification or transgene.

Selected Publications 

 ·  C. Huang, C. Yang, D. Pang,C. Li,H. Gong,X. Cao,X. He, X. Chen, B. Mu, Y. Cui, W. Liu,Q. Luo, A. Cheng, L. Jia, M. Chen, B. Xiao, Z. Chen, Animal models of male subfertility targeted on LanCL1-regulated spermatogenic redox homeostasis. Lab animal 51, 133-145 (2022). (Cover Article)    

 ·  C. Huang, M. Chen, D. Pang, D. Bi, Y. Zou, X. Xia, W. Yang, L. Luo, R. Deng, H. Tan, L. Zhou, S. Yu, L. Guo, X. Du, Y. Cui, J. Hu, Q. Mao, P. F. Worley, B. Xiao, Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival. Developmental cell 30, 479-487 (2014). (Featured Article)    

 ·  C. Huang, H. Gong, B. Mu, X. Lan, C. Yang, J. Tan, W. Liu, Y. Zou, L. Li, B. Feng, X. He, Q. Luo, Z. Chen, BAF-L Modulates Histone-to-Protamine Transition during Spermiogenesis. International journal of molecular sciences 23,  (2022).    

 ·  C. Huang, X. Peng, D. J. Pang, J. Li, B. S. Paulsen, F. Rise, Y. L. Chen, Z. L. Chen, R. Y. Jia, L. X. Li, X. Song, B. Feng, Z. Q. Yin, Y. F. Zou, Pectic polysaccharide from Nelumbo nucifera leaves promotes intestinal antioxidant defense in vitro and in vivo. Food & function 12, 10828-10841 (2021).

 ·  L. Li, X. Lan, X. Peng, S. Shi, Y. Zhao, W. Liu, Q. Luo, L. Jia, B. Feng, Z. Chen, Y. Zou^*, C. Huang^*, Polysaccharide from Salviae miltiorrhizae Radix et Rhizoma Attenuates the Progress of Obesity-Induced Non-Alcoholic Fatty Liver Disease through Modulating Intestinal Microbiota-Related Gut-Liver Axis. International journal of molecular sciences 23,  (2022).

 ·  L. Jia, Z. Chen, T. Pan, Y. Xia, J. He, A. Jahangir, X. Wei, W. Liu, R. Shi, C. Huang^*, Q. Luo^*, TRIM67 Deficiency Exacerbates Hypothalamic Inflammation and Fat Accumulation in Obese Mice. International journal of molecular sciences 23,  (2022).

 ·  Q. Luo, A. Jahangir, J. He, C. Huang^*, Y. Xia, L. Jia, X. Wei, T. Pan, Y. Du, B. Mu, H. Gong, W. Liu, S. Ur-Rehman, K. Pan, Z. Chen^*, Ameliorating Effects of TRIM67 against Intestinal Inflammation and Barrier Dysfunction Induced by High Fat Diet in Obese Mice. International journal of molecular sciences 23,  (2022).

 ·  C. Huang, X. Wei, Q. Luo, Y. Xia, T. Pan, J. He, A. Jahangir, L. Jia, W. Liu, Y. Zou, L. Li, H. Guo, Y. Geng, Z. Chen, Loss of TRIM67 Attenuates the Progress of Obesity-Induced Non-Alcoholic Fatty Liver Disease. International journal of molecular sciences 23,  (2022).    

 ·  J. Hu, X. Cao, D. Pang, Q. Luo, Y. Zou, B. Feng, L. Li, Z. Chen, C. Huang^*, Tumor grade related expression of neuroglobin is negatively regulated by PPARgamma and confers antioxidant activity in glioma progression. Redox biology 12, 682-689 (2017).

 ·  Y. F. Zou, M. Chen, Y. P. Fu, Z. K. Zhu, Y. Y. Zhang, B. S. Paulsen, F. Rise, Y. L. Chen, Y. Z. Yang, R. Y. Jia, L. X. Li, X. Song, H. Q. Tang, B. Feng, C. Lv, G. Ye, D. T. Wu, Z. Q. Yin, C. Huang^*, Characterization of an antioxidant pectic polysaccharide from Platycodon grandiflorus. International journal of biological macromolecules 175, 473-480 (2021).

 ·  C. Huang, R. Yao, Z. Zhu, D. Pang, X. Cao, B. Feng, B. S. Paulsen, L. Li, Z. Yin, X. Chen, R. Jia, X. Song, G. Ye, Q. Luo, Z. Chen, Y. Zou, A pectic polysaccharide from water decoction of Xinjiang Lycium barbarum fruit protects against intestinal endoplasmic reticulum stress. International journal of biological macromolecules 130, 508-514 (2019).

 ·  C. Huang, X. Cao, X. Chen, Y. Fu, Y. Zhu, Z. Chen, Q. Luo, L. Li, X. Song, R. Jia, Z. Yin, B. Feng, Y. Zou, A pectic polysaccharide from Ligusticum chuanxiong promotes intestine antioxidant defense in aged mice. Carbohydrate polymers 174, 915-922 (2017).

 ·  D. Pang, C. Yang, Q. Luo, C. Li, W. Liu, L. Li, Y. Zou, B. Feng, Z. Chen, C. Huang^*, Soy isoflavones improve the oxidative stress induced hypothalamic inflammation and apoptosis in high fat diet-induced obese male mice through PGC1-alpha pathway. Aging 12, 8710-8727 (2020).

 ·  D. Pang, C. Yang, C. Li, Y. Zou, B. Feng, L. Li, W. Liu, Q. Luo, Z. Chen, C. Huang^*, Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-kappaB pathway. Biology open 9,  (2020).

 ·  C. Huang, W. Ma, Q. Luo, L. Shi, Y. Xia, C. Lao, W. Liu, Y. Zou, A. Cheng, R. Shi, Z. Chen, Iron overload resulting from the chronic oral administration of ferric citrate induces parkinsonism phenotypes in middle-aged mice. Aging 11, 9846-9861 (2019).

 ·  D. Pang, C. Li, C. Yang, Y. Zou, B. Feng, L. Li, W. Liu, Y. Geng, Q. Luo, Z. Chen, C. Huang^*, Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide. Oxidative medicine and cellular longevity 2019, 1805635 (2019).

 ·  C. Huang, Z. Zhu, X. Cao, X. Chen, Y. Fu, Z. Chen, L. Li, X. Song, R. Jia, Z. Yin, G. Ye, B. Feng, Y. Zou, A Pectic Polysaccharide from Sijunzi Decoction Promotes the Antioxidant Defenses of SW480 Cells. Molecules 22,  (2017).

 ·  H. Chao, P. Dejiang, L. Qihui, C. Xiaolin, G. Qi, S. Liangqin, L. Wentao, Z. Yuanfeng, L. Lixia, C. Zhengli, Soy Isoflavones Regulate Lipid Metabolism through an AKT/mTORC1 Pathway in Diet-Induced Obesity (DIO) Male Rats. Molecules 21,  (2016).