Xinghong Zhao

Identtity

l Associate Professor

Education

Doctorate

l Date:  22-06-2020

l University:   University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute, The Netherlands.

l Thesis title: ‘Enhancing the antimicrobial potential of lanthipeptides by employing different engineering strategies’

l Supervisor:  Prof. Oscar P. Kuipers [Elected Member, Royal Netherlands Academy of Arts and Sciences (KNAW), Elected Board Member, European Academy of Microbiology (EAM)]

Training and Professional Experience

l Aug. 21– present  Associate Professor, Department of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, China.

l Sept. 19 – Jul. 21  Postdoc, Chemical Biology approaches toward novel cyclic peptide antibiotics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands.

l Xinghong Zhao obtained a Master’s degree in Pharmacology at the Sichuan Agricultural University in 2015 and got his Ph.D. degree at the University of Groningen in biomolecular sciences and biotechnology: Lantibiotic engineering in 2020. He did a postdoc at the University of Groningen from 2019 to 2021. He was appointed associate professor of the Department of Pharmacy at the Sichuan Agricultural University in 2021.

Research Interests

l Specific current interests are synthetic biology, antimicrobial mechanism of novel peptides, novel antimicrobial peptide development via genome mining and machine learning approaches, and targeted nanodelivery systems for antimicrobials and vaccines.

Membership of Professional Society

l Associate Editor of ACS Infectious Diseases, 2024-present.

l Guest Editor of Frontiers in Microbiology, 2022-2023.

l Review Editor of Frontiers in Chemistry, 2022-present.

l Member, Royal Dutch Society for Microbiology (KNVM).

Selected Publications

l Xinghong Zhao^#, *, Xinyi Zhong^#, Shinong Yang^#, Jiarong Deng, Kai Deng, Zhengqun Huang, Yuanfeng Li, Zhongqiong Yin*, Yong Liu*, Jakob H. Viel, and Hongping Wan*. "Guiding antibiotics towards their target using bacteriophage proteins." Nature Communications, 2024, 15: 5287. （IF = 16.6）

l Hongping Wan^#,*, Xinyi Zhong^#, Shinong Yang^#, Jiarong Deng^#, Xu Song, Yong Liu*, Yuanfeng Li*, Zhongqiong Yin, Xinghong Zhao*. "Enhancing the Therapeutic Potential of Peptide Antibiotics Using Bacteriophage Mimicry Strategies. " Advanced Science, 2024, 2411753. (IF = 14.3)

l Xinghong Zhao, Zhibo Li, and Oscar P. Kuipers*. "Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification." Cell Chemical Biology, 2020, 27(10): 1262-1271.（IF = 9.039）

l Xiaowen Hu, Dongdong Li, Huaping Li, Yinzi Piao*, Hongping Wan, Tieli Zhou, Mahdi Karimi, Xinghong Zhao*, Yuanfeng Li*, Linqi Shi, Yong Liu*. "Reaction-Induced Self-Assembly of Polymyxin Mitigates Cytotoxicity and Reverses Drug Resistance." Advanced Materials, 2024, 2406156. (IF = 27.4)

l Kai Deng^#, Zhengqun Huang^#, Bo Jing, Lin Zhu, Yumei Feng, Qin Jiang, Zhiwen Xu, Hongping Wan*, and Xinghong Zhao*. "Mucoadhesive chitosan-catechol as an efficient vaccine delivery system for intranasal immunization." International Journal of Biological Macromolecules, 2024, 133008. （IF = 8.2）

l Yumeng Wang^#, Xinghong Zhao^#, Xingjian Zhou^#, Juqin Dai, Xiaowen Hu, Yinzi Piao, Guangyue Zu, Jian Xiao*, Keqing Shi*, Yong Liu*, Yuanfeng Li*, and Linqi Shi. "A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing." Journal of Controlled Release, 2024, 368:740-755.（IF = 10.8）

l Hongping Wan^#,*, Kai Deng^#, Zhengqun Huang^#, Yunhan Yang, Bo Jing, Yumei Feng, Yuanfeng Li, Yong Liu, Mingqin Liu, and Xinghong Zhao*. "Pathogen-mimicking Nanoparticles Based on Rigid Nanomaterials as an Efficient Subunit Vaccine Delivery System for Intranasal Iimmunization." Advanced Healthcare Materials, 2024, 2401120.（IF = 10）

l Xinghong Zhao^#, *, Xinyi Zhong^#, Shinong Yang^#, Kai Deng, Lu Liu, Xu Song, Yuanfeng Zou, Lixia Li, Xun Zhou, Renyong Jia, Juchun Lin, Huaqiao Tang, Gang Ye, Jianqing Yang, Shan Zhao, Yifei Lang, Hongping Wan*, Zhongqiong Yin*, and Oscar P. Kuipers. "Elucidating the Mechanism of Action of the Gram-Negative-Pathogen-Selective Cyclic Antimicrobial Lipopeptide Brevicidine." Antimicrobial Agents and Chemotherapy, 2023: e00010-23.（IF = 5.938）

l Xinghong Zhao, Zhongqiong Yin, Eefjan Breukink, Gert N. Moll, and Oscar P. Kuipers*. "An engineered double lipid II binding motifs-containing lantibiotic displays potent and selective antimicrobial activity against Enterococcus faecium." Antimicrobial Agents and Chemotherapy, 2020, 64(6): e02050-19.（IF = 5.938）

l Yongcheng He^#, Jiarong Deng^#, Xinyi Zhong^#, Shujun Dai, Xu Song, Yuanfeng Zou, Gang Ye, Xun Zhou, Zhongqiong Yin, Hongping Wan*, Xinghong Zhao*. "Engineered Hybrid Lantibiotic that Selectively Combats Infections Caused by Staphylococcus aureus." ACS Infectious Diseases, 2024.（IF = 4）