Lanlan Jia

Identity

·  Assistant professor  

Education

·  09/2015-06/2021, PhD in Cell Biology, Sichuan University

·  09/2011-06/2015, B.S. in Biotechnology, Sichuan University

Training and Professional Experience

·  2018-2019,      trainee, Department of Neuroscience, Johns Hopkins University School of Medicine

·  2022-now, Lecturer, Sichuan Agricultural University College of Veterinary Medicine

Research Interests

·  Focus on the identification of key genes in the developmental process of the mouse nervous system and their functional studies, especially role of metabolic coupling between glial cells and neurons in the genesis, maintenance and repair of nervous system under physiological and injury conditions.

Selected Publications 

·  Jia, L., Liao, M., Mou, A., Zheng, Q., Yang, W., Yu, Z., Cui, Y., Xia, X., Qin, Y., Chen, M., et al. (2021). Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability. Dev Cell 56, 2980-2994 e2986.

·  Yang, W., Pang, D., Chen, M., Du, C., Jia, L., Wang, L., He, Y., Jiang, W., Luo, L., Yu, Z., et al. (2021). Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation. Dev Cell 56, 811-825 e816.

·  Yu, Z., Yang, Z., Ren, G., Wang, Y., Luo, X., Zhu, F., Yu, S., Jia, L., Chen, M., Worley, P.F., et al. (2022). GATOR2 complex-mediated amino acid signaling regulates brain myelination. Proc Natl Acad Sci U S A 119.

·  Jia, L., Chen, Z., Pan, T., Xia, Y., He, J., Jahangir, A., Wei, X., Liu, W., Shi, R., Huang, C., et al. (2022). TRIM67 Deficiency Exacerbates Hypothalamic Inflammation and Fat Accumulation in Obese Mice. International journal of molecular sciences 23.

·  Luo, Q., Jia, L., Huang, C., Qi, Q., Jahangir, A., Xia, Y., Liu, W., Shi, R., Tang, L., and Chen, Z. (2022). Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway. International journal of molecular sciences 23.、

·  Huang, C., Yang, C., Pang, D., Li, C., Gong, H., Cao, X., He, X., Chen, X., Mu, B., Cui, Y., et al. (2022). Animal models of male subfertility targeted on LanCL1-regulated spermatogenic redox homeostasis. Lab animal 51, 133-145.