Shun Chen

Identity

·  Professor

·  Dean of College of Veterinary Medicine

·  Director of Preventive Veterinary Research Institute  

Education 

·  2000-2004: Bachelor of Science, Sichuan Agricultural University, Chengdu, China.

·  2004-2010: Doctor of Agriculture, Sichuan Agricultural University, Chengdu, China.

·  2010-2011: Postdoctoral Fellows, School of Life Science and Technology, UESTC, Chengdu, China

Training and Professional Experience

·  2011-2012: Assistant professor of College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

·  2012-2018: Associate professor of College of Veterinary Medicine, Sichuan Agricultural University

·  2019-present: Full Professor (permanent) College of Veterinary Medicine, Sichuan Agricultural University

·  2015–2020: Vice Director of Preventive Veterinary Research Institute, College of Veterinary Medicine, Sichuan Agricultural University

·  2020-2023: Vice Dean of College of Veterinary Medicine, Sichuan Agricultural University

·  2020-present: Director of Preventive Veterinary Research Institute, Sichuan Agricultural  University

·  2023-present: Dean of College of Veterinary Medicine, Sichuan Agricultural University

Research Interests

·  Molecular virology of avian flavivirures, including the role of UTR and NSs in viral genome RNA replication, polyprotein processing, and its interplay with host innate immunology.

·  The genome evolution on viral fitness following host shifts in the mosquitoes-transmitted flavivirus.

Awards and Honors

·  2012, The Ministry of Education Technology Invention Award (the first award), the fifth completed

·  2013, The National Award for Technological Invention (the Second Award), the fifth completed

·  2017, The Sichuan Technology Progress Award (the Second award), the seventh completed

· 2018, The Award of Fok Ying-Tong Education Foundation for Outstanding Young Teachers in the Higher Education Institutions of China

·  2018, The Top 100 Distinguished Young People in Sichuan

·  2019, The Ministry of Agriculture and Rural Affairs Excellent Innovation Team Award of Ministry

·  2019, The  Ministry of Agriculture and Rural Affairs Science Popularization Award

·  2020, The Cheung Kong (Changjiang) Scholars Program of Ministry of Education of China Young Scholars

·  2021, The Sichuan Province youth talent support program

Selected Publications 

·  Zhen Wu, Tao Hu, Andres Merits, Yu He, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Sai Mao, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Qun Gao, Di Sun, Anchun Cheng*, Shun Chen*. Toll-like receptor 4 and lipopolysaccharide from commensal microbes regulate Tembusu virus infection. J Biol Chem. 2022，Dec; 298(12):102699 .

·  Li Mao, Yu He, Zhen Wu, Xiaoli Wang, Jiaqi Guo, Senzhao Zhang, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Sai Mao, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Qun Gao, Di Sun, Anchun Cheng*, Shun Chen*. Stem-Loop I of the Tembusu Virus 3'-Untranslated Region Is Responsible for Viral Host-Specific Adaptation and the Pathogenicity of the Virus in Mice. Microbiology Spectrum, 10th Oct 2022, e0244922.

·  Yu He, Jiaqi Guo, Xiaoli Wang, Senzhao Zhang, Li Mao, Tao Hu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou,Qun Gao, Di Sun, Anchun Cheng* and Shun Chen*. 2022. Assembly-defective Tembusu virus ectopically expressing capsid protein is an approach for live-attenuated flavivirus vaccine development. npj Vaccines 7, 51.

·  Wang T, Merits A, Wu Y, Wang M, Jia R, Zhu D, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Liu Y, Zhang L, Yu Y, Pan L, Chen S*, Cheng A*. 2020. cis-Acting Sequences and Secondary Structures in Untranslated Regions of Duck Tembusu Virus RNA Are Important  for Cap-Independent Translation and Viral Proliferation. Journal of Virology 94. (16).

·  Wu Z, Zhang W, Wu Y, Wang T, Wu S, Wang M, Jia R, Zhu D, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Liu Y, Zhang L, Yu Y, Pan L, Merits A, Chen S*, Cheng A*. 2019. Binding of the Duck Tembusu Virus Protease to STING Is Mediated by NS2B and Is Crucial for STING Cleavage and for Impaired Induction of IFN-beta. Journal of Immunology 203:3374-3385.

·  Zhang W, Jiang B, Zeng M, Duan Y, Wu Z, Wu Y, Wang T, Wang M, Jia R, Zhu D, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Liu Y, Zhang L, Yu Y, Pan L, Chen S*, Cheng A*. 2020. Binding of Duck Tembusu Virus Nonstructural Protein 2A to Duck STING Disrupts Induction of Its Signal Transduction Cascade To Inhibit Beta Interferon Induction. Journal of Virology 94(9), e01850-19

·  Chen S*, Yang C, Zhang W,Mahalingam S, Wang M, Cheng A*. 2018. Flaviviridae virus nonstructural proteins 5 and 5A mediate viral immune evasion and are promising targets in drug development. Pharmacology & Therapeutics 190:1-14.

·  Wu Z, Wu Y, Zhang W, Merits A,Simmonds P, Wang M, Jia R, Zhu D, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Huang J, Ou X, Mao S, Liu Y, Zhang L, Yu Y, Tian B, Pan L, Rehman MU, Chen S*, Cheng A*. 2020. The First Nonmammalian Pegivirus Demonstrates Efficient In Vitro Replication and High Lymphotropism. Journal of Virology 94:e01150-20.

·  Zhen Wu, Tao Hu, Weiqiong Chen, Yao Cheng, Mingshu Wang,Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu,Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Anchun Cheng*, Shun Chen*. he autophagy-related degradation of MDA5 by Tembusu virus nonstructural 2B disrupts IFNβ production. FASEB J,2022 Jul, 36(7):e22417.

·  Chen S*, Zhang W, Wu Z,Zhang J, Wang M, Jia R, Zhu D, Liu M, Sun K, Yang Q, Wu Y, Chen X, Cheng A*. 2017. Goose Mx and OASL Play Vital Roles in the Antiviral Effects of Type I, II, and III Interferon against Newly Emerging Avian Flavivirus. Frontiers in Immunology 8:1006.

·  Zhang W, Zeng M, Jiang B, Lu T,Guo J, Hu T, Wang M, Jia R, Zhu D, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Ou X, Liu Y, Zhang L, Yu Y, Pan L, Cheng A, Chen S*. 2021. Amelioration of Beta Interferon Inhibition by NS4B Contributes to Attenuating Tembusu Virus Virulence in Ducks. Frontiers in Immunology 12:671471.

·  Chen S, Cheng A, Wang M.2013. Innate sensing of viruses by pattern recognition receptors in birds.Veterinary Research 44:82.