Hong Dong

Identity

·  Professor

E-mail

·  dong.hong55555@163.com

Education

· 09/2014-06/2018, Ph.D., Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, China.

· 09/2011-06/2014, M.S., Preventive Veterinary Medicine, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China. (Joint training of Master at Division of Swine Infectious Diseases of the Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences)

· 09/2006-06/2010, B.S., Biotechnology, College of Life Sciences, Gansu Agricultural University, Lanzhou, China.

Training and Professional Experience

· 03/2026-now, Professor (Tenured), Sichuan Agricultural University College of Veterinary Medicine, Chengdu, China

· 06/2023-01/2026, Research Senior Associate, Ohio State University, Columbus, Ohio, USA

· 01/2020-05/2023, Postdoctoral Scholar, Ohio State University, Columbus, Ohio, USA

· 06/2018-12/2019, Post-Doctoral Associate, North Dakota State University, Fargo, North Dakota, USA

Research Interests

Antiviral immunity; Immuno-metabolism; Innate immunity; Adaptive immunity; Virology; Cell death and inflammation; Glucose metabolism

Awards and Honors

· 2025, OSU IDI Viruses and Emerging Pathogens Program Research Excellence Travel Award, Ohio State university

· 2024, Postdoctoral Scholar Travel Award, American Society for Virology (ASV)

· 2024, Trainee Poster Award, American Association of Immunologists (AAI)

· 2021, Trainee Abstract Award, American Association of Immunologists (AAI)

Selected Publications

· Dong H, Liang C, Zhang J, Wu W, Kumar N, Liu Z, Sun Y, Liao Z, Cheng X, Yu Y, Zhang Y, Holtzman MJ, Li J, Gowdy KM, Thomas PG, Badjic JD, Ma A, Ma Q, Yount JS, Liu SL, Wen H. 2025. O-GlcNAc transferase plays dual antiviral roles by integrating innate immunity and lipid metabolism. Nat Commun. 16(1):7721.

· Dong H, Zhao B, Chen J, Liu Z, Li X, Li L, Wen H. 2022. Mitochondrial calcium uniporter promotes phagocytosis-dependent activation of the NLRP3 inflammasome. Proc Natl Acad Sci U S A. 119(26): e2123247119.

· Dong H, Liu Z, Wen H. 2022. Protein O-GlcNAcylation regulates innate immune cell function. Front Immunol. Feb 3;13:805018.

· Chen J #, Zhao B #, Dong H #, Li T, Cheng X, Gong W, Wang J, Zhang J, Xin G, Yu Y, Lei Y, Black J, Li Z, Wen H. 2024. Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway. Elife. 4:13:RP94849. (#: Co-first author)

· Dong H, Zhou L, Ge X, Guo X, Han J, Yang H. 2018. Porcine reproductive and respiratory syndrome virus nsp1β and nsp11 antagonize the antiviral activity of cholesterol-25-hydroxylase via lysosomal degradation. Vet Microbiol 223:134-143.

· Dong H, Zhou L, Ge X, Guo X, Han J, Yang H. 2018. Antiviral effect of 25hydroxycholesterol against porcine reproductive and respiratory syndrome virus in vitro. Antivir Ther 23(5):395-404.

· Zhao B, Gong W, Ma A, Chen J, Velegraki M, Dong H, Liu Z, Wang L, Okimoto T, Jones D, Lei Y, Long M, Oestreich K, Ma Q, Xin G, Carbone D, He K, Li Z, Wen H. 2022. SUSD2 suppresses CD8+ T cell antitumor immunity by targeting IL-2 receptor signaling. Nat Immunol. Nov;23(11):1588-1599.

· Li D, Dong H, Li S, Munir M, Chen J, Luo Y, Sun Y, Liu L, Qiu HJ. 2013a. Hemoglobin subunit beta interacts with the capsid protein and antagonizes the growth of classical swine fever virus. J Virol 87:5707-5717.