Yifei Lang

Identity

· Associate Professor    

Education

· 10/2014-05/2020,PhD in Virology, Utrecht University, the Netherlands

·  09/2011-06/2014,M.S. in Veterinary Microbiology, Chinese Academy of Agricultural Sciences

·  09/2006-06/2010, B.S. in Biotechnology, Shandong Agricultural University

Training and Professional Experience

·  06/2020-05/2021, Postdoctoral Researcher, Utrecht University, the Netherlands

Research Interests

· Focus on the epidemiology, pathogenicity and transmission mechanism of Coronaviruses

Selected Publications

·  Li, Z.^#, Lang, Y.^#,   Liu, L., Bunyatov, M., Sarmiento, A.I., de Groot, R.J. & Boons, G.J.   (2021). Synthetic O-Acetylated Sialosides Facilitate   Functional Receptor Identification for Human Respiratory Viruses. Nature Chemistry 13, 496–503 (2021)   

·   Lang, Y., Li, W., Li, Z., Koerhuis, D., van den Burg,   A.C.S., Rozemuller, E., Bosch, BJ., van Kuppeveld, F.J., Boons, G.J.,   Huizinga, E.G., van der Schaar, H.M.& de Groot, R.J. (2020). Coronavirus hemagglutinin-esterase and spike proteins coevolve for   functional balance and optimal virion avidity. Proceedings of the National   Academy of Sciences of the United   States of America 117 (41)   25759-25770.

·  Hulswit, R.J.G.^#,   Lang, Y.^#, Bakkers, M.J.G.^#, Li, W., Li, Z.,   Schouten, A., Ophorst, B., van Kuppeveld, F.J., Boons, G.J., Bosch, B.J. and   Huizinga, E.G & de Groot, R.J. (2019). Human coronaviruses OC43 and HKU1   bind to 9-O-acetylated sialic acids via a conserved receptor binding site in   spike protein domain A. Proceedings of the National Academy of   Sciences of the United States of America 116(7), pp.2681-2690

·  Hurdiss, D.L., Drulyte, I.^#, Lang, Y.^#, Shamorkina T.M., Pronker M.F., van   Kuppeveld, F.J., Snijder, J & de Groot, R.J. (2020). Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals   architectural changes arising from prolonged circulation in humans. Nature   Communications 11, 4646.

· Tortorici, M.A,   Walls, A.C, Lang, Y., Wang,   C., Li, Z., Koerhuis, D., Boons, G.J., Bosch, BJ., Rey, F. A., de Groot,   R.J. & Veesler, D. (2019).Structural basis for human coronavirus   attachment to sialic acid receptors. Nature   structural & molecular biology, 26, pp.481–489
· Li, W., Hulswit, R. J., Widjaja, I., Raj, V. S., McBride, R., Peng, W.,   Widagdo, W., Tortorici, M.A., van Dieren, B., Lang, Y., van Lent, J. W., Paulson, J.C., de Haan, C.A.M.,   de Groot, R.J., van Kuppeveld, F.J.M., Haagmans, B.L & Bosch, B.J.   (2017). Identification of sialic acid-binding   function for the Middle East respiratory syndrome coronavirus spike   glycoprotein. Proceedings of the National Academy of Sciences of the United States of America 114(40), E8508-E8517.

· Bakkers, M.J.G., Lang, Y.,   Feitsma, L.J., Hulswit, R.J.G., de Poot, S.A.H., van Vliet, A.L.W., Margine,   I., Mijnes- de Groot, J.D.F., van Kuppeveld, F.J.M., Langereis, M.A.,   Huizinga, E.G. & de Groot, R.J. (2017). Betacoronavirus adaptation to humans involved progressive loss of   hemagglutinin-esterase lectin activity. Cell Host & Microbe 21(3),   356-366.

·  Lang, Y., Gao, S., Du,   J., Shao, J., Cong, G., Lin, T., Zhao F., Liu L. & Chang, H. (2014).   Polymorphic genetic characterization of E2 gene of bovine viral diarrhea   virus in China. Veterinary Microbiology. 174(3), 554-559.

·  Gao, S., Du, J.,   Shao, J., Lang, Y., Lin,   T., Cong, G., Zhao, F., Belák, S., Liu, L., Chang, H. & Yin, H. (2014).   Genome analysis reveals a novel genetically divergent subgenotype of bovine   viral diarrhea virus in China. Infection,   Genetics and Evolution. 21:489-91.

· Gao, S., Luo,   J., Du, J., Lang, Y., Cong,   G., Shao, J., Lin, T., Zhao, F., Belák, S., Liu, L., Chang, H. & Yin, H.   (2013). Serological and molecular evidence for natural infection of Bactrian   camels with multiple subgenotypes of bovine viral diarrhea virus in Western   China. Veterinary Microbiology. 163(1-2):172-6.