Zhen Wu

Identity

l Associate Professors  

Education

l 09/2018-12/2022, PhD in Preventive Veterinary Medicine, Sichuan Agricultural University

l 10/2021-10/2022, Joint PhD in Virology, KU Leuven, Belguim

l 09/2016-06/2018, M.S. in Preventive Veterinary Medicine, Sichuan Agricultural University

Training and Professional Experience

l 06/2023-now, Associate Professors, Sichuan Agricultural University College of Veterinary Medicine

Research Interests

l Mechanisms utilized by flaviviruses to modulate host innate immunity

l The role of novel IFN-stimulated genes (ISGs) in host resistance to flaviviruses infection

Awards and Honors

l ‘Sichuan Province natural science second prize’ third complete

Selected Publications

1. Shun Chen, Zhen Wu, Mingshu Wang and Anchun Cheng. Innate immune evasion mediated by flaviviridae non-Structural proteins [J].Viruses-Basel,2017, 9.

2. Shun Chen, Zhen Wu, Anchun Cheng, et al.Duck stimulator of interferon genes plays an important role in host anti-duck plague virus infection through an IFN-dependent signalling pathway [J].Cytokine, 2017, 9.

3. Zhen Wu, Anchun Cheng, Shun Chen, et al.Binding of the Duck Tembusu Virus Protease to STING Is Mediated by NS2B and Is Crucial for STING Cleavage and for Impaired Induction of IFN-β [J].Journal of Immunology,2019, 12.

4. Zhen Wu, Tao Hu, Anchun Cheng, Shun Chen, et al. The autophagy-related degradation of MDA5 by Tembusu virus nonstructural 2B disrupts IFNβproduction [J].The FASEB Journal,2022, 6.

5. Zhen Wu, Anchun Cheng, Shun Chen, et al. The G92 NS2B mutant of Tembusu virus is involved in severe defects in progeny virus assembly [J].Veterinary Microbiology, 2022, 4.

6. Zhen Wu, Anchun Cheng, Shun Chen, et al. Toll-like receptor 4 and lipopolysaccharide from commensal microbes regulate Tembusu virus infection[J].Journal of Biological Chemistry, 2022,11.

7. Wei Zhang, Zhen Wu, Anchun Cheng, Shun Chen, et al. Binding of Duck Tembusu virus nonstructural protein 2A to duSTING disrupts the induction of its signal transduction cascade to inhibit IFN-β induction [J].Journal of Virology, 2020, 2.

8. Zhen Wu, Yuanyuan Wu, Anchun Cheng, Shun Chen, et al. The First Nonmammalian Pegivirus Demonstrates Efficient In Vitro Replication and High Lymphotropism [J]. Journal of Virology, 2020. 9.

9. Zhen Wu, Yuanyuan Wu, Anchun Cheng, Shun Chen, et al. Emergence of a novel pegivirus species in southwest China showing a high rate of coinfection with parvovirus and circovirus in geese [J].Poultry Science,2021, 8.

10. Tao Hu, Zhen Wu, Shun Chen, Anchun Cheng, et al. The key amino acids of E protein involved in early flavivirus infection: viral entry [J].Virology Journal,2021. 7.

11. Tao Hu, Zhen Wu, Shun Chen, Anchun Cheng, et al.Substitutions at Loop Regions of TMUV E Protein Domain III Differentially Impair Viral Entry and Assembly [J].Frontiers in Microbiology.2021.6.