Yu He

Identity

  ·  Assistant  Professor   

Education

  ·  09/2012-06/2016, Bachelor of Science, Sichuan Agricultural University,Chengdu, China

  ·   09/2016-12/2022,PhD in Preventive Veterinary Medicine, Sichuan Agricultural University,Chengdu, China

Training and Professional Experience

  ·  2023-now, Lecturer, College of Veterinary Medicine, Sichuan Agricultural University

Research Interests

  ·   The molecular virology of avian flavivirus, mainly focus on the roles of nonstructural proteins and UTRs in viral replication and transmission (from mosquito to vertebrate host).

  ·   Novel vaccine designs for virus-related avian disease.

Selected Publications

  ·   He Y,Guo J, Wang X, et al. Assembly-defective Tembusu virus ectopically expressing capsid protein is an approach for live-attenuated flavivirus vaccine development. npj Vaccines. 2022：51.

  ·   He Y,Wang X, Guo J, et al. Replication/Assembly Defective Avian Flavivirus With Internal Deletions in the Capsid Can Be Used as an Approach for Living Attenuated Vaccine. Frontiers in Immunology. 2021: 3028.

  ·   He Y,Wang M, Chen S, et al. The role of capsid in the flaviviral life cycle and perspectives for vaccine development. Vaccine. 2020.

  ·   He Y,Wang A, Chen S, et al. Differential immune-related gene expression in the spleens of duck Tembusu virus-infected goslings. Veterinary Microbiology. 2017, 212: 39-47.

  ·   He Y, Liu P, Wang T, et al. Genetically stable reporter virus, subgenomic replicon and packaging system of duck Tembusu virus based on a reverse genetics system. Virology. 2019, 533: 86-92.

  ·   Chen S, He Y, Zhang R, et al. Establishment of a reverse genetics system for duck Tembusu virus to study virulence and screen antiviral genes. Antiviral Research. 2018, 157: 120-127.

  ·   Mao L, He Y, Wu Z, et al. Stem-Loop I of the Tembusu Virus 3′-Untranslated Region Is Responsible for Viral Host-Specific Adaptation and the Pathogenicity of the Virus in Mice. Microbiology Spectrum, 2022:e02449-22.

  ·   Wang X, He Y, Guo J, et al. Construction of an Infectious Clone for Mosquito-Derived Tembusu Virus Prototypical Strain. Virologica Sinica.2021: 1-4.

  ·   Guo J, He Y, Wang X, et al. Stabilization of a full-length infectious cDNA clone for duck Tembusu virus by insertion of an intron. Journal of Virological Methods. 2020, 283: 113922.