Xumin Ou

Identity

   · Principal nvestigator  

Education

   · 09/2017-11/2021,Doctor of Medicine, Erasmus MC-University Medical Center, the Netherlands

   · 12/2012-06/2019,PhD. in Preventive Veterinary Medicine, Sichuan Agricultural University

   · 09/2010-06/2012,B.S. in Animal Medicine, Sichuan Agricultural University

Training and Professional Experience

   · 2019-now,Lecturer, Sichuan Agricultural University College of Veterinary Medicine

Research Interests

   · Focus on role of tRNA biology in viral Hepatitis of both human and animal, as well as in cancer development.

   · Novel therapeutical strategies by targeting pathogenic tRNAs or relatives.

Awards and Honors

   · 2017, March. China Scholarship Council (CSC) Scholarship

   · 2018, National Scholarship for Graduate Students (¥30,000), China

Selected Publications 

   · Ou, X., Cao, J., Cheng, A., Peppelenbosch, M.P. and Pan, Q., Errors in translational decoding: tRNA wobbling or misincorporation?. PLoS genetics, 2019. 15(3), p.e1008017.

   · Ou, X., Ma, B., Zhang, R., Miao, Z., Cheng, A., Peppelenbosch, M.P. and Pan, Q., A simplified qPCR method revealing tRNAome remodeling upon infection by genotype 3 hepatitis E virus. FEBS letters, 2020. 594(12), pp.2005-2015.

   ·  Ou, X., Peng, W., Yang, Z., Cao, J., Wang, M., Peppelenbosch, M.P., Pan, Q. and Cheng, A., Evolutionarily missing and conserved tRNA genes in human and avian. Infection, Genetics and Evolution, 2020. 85, p.104460.

   · Zhang, R., Noordam, L., Ou, X., Ma, B., Li, Y., Das, P., Shi, S., Liu, J., Wang, L., Li, P. and Verstegen, M.M., The biological process of lysine‐tRNA charging is therapeutically targetable in liver cancer. Liver International, 2021. 41(1), pp.206-219.

   ·  Ou, X., Wang, M., Mao, S., Cao, J., Cheng, A., Zhu, D., Chen, S., Jia, R., Liu, M., Yang, Q. and Wu, Y., Zhao, X. Zhang, S., Liu, Y., Yu, Y., Zhang, L., Chen, X., Peppelenbosch, M.P., Pan, Q. and Cheng, A., Incompatible translation drives a convergent evolution and viral attenuation during the development of live attenuated vaccine. Frontiers in cellular and infection microbiology, 2018. 8, p.249.

   ·  Ou, X., Mao, S., Cao, J., Cheng, A., Wang, M., Zhu, D., Chen, S., Jia, R., Liu, M., Sun, K. and Yang, Q., Wu, Y., Chen, X., Comparative analysis of virus-host interactions caused by a virulent and an attenuated duck hepatitis A virus genotype 1. PloS one, 2017. 12(6), p.e0178993.

   ·  Ou, X., Yang, Z., Zhu, D., Mao, S., Wang, M., Jia, R., Chen, S., Liu, M., Yang, Q., Wu, Y., Zhao, X. Zhang, S., huang, J., Gao, Q., Liu, Y., Zhang, L., Peppelenbosch, M.P., Pan, Q. and Cheng, A., Tracing genetic signatures of bat-to-human coronaviruses and early transmission of North American SARS-CoV-2. Transbound Emerg Dis 2021,00:1-13. doi: 10.1111/tbed.14148

   ·  Miao, Z., Zhang, S., Ou, X., Li, S., Ma, Z., Wang, W., Peppelenbosch, M.P., Liu, J. and Pan, Q., 2020. Estimating the global prevalence, disease progression, and clinical outcome of hepatitis delta virus infection. The Journal of infectious diseases, 221(10), pp.1677-1687.

   ·  Li, Y., Qu, C., Yu, P., Ou, X., Pan, Q. and Wang, W., The interplay between host innate immunity and hepatitis E virus. Viruses, 2019. 11(6), p.541.

   ·  Mao, S., Ou, X., Wang, M., Sun, D., Yang, Q., Wu Y., Jia R., Zhu D., Zhao X., Chen, S., Liu, M., Zhang, S., Huang, J., Gao, Q., Liu Y., Yu, Y., Zhang, L., Tian B., Pan, L., Chen, X., Cheng, A. Duck hepatitis A virus 1 has lymphoid tissue tropism altering the organic immune responses of mature ducks. Transbound Emerg Dis. 2020.doi:10.1111/tbed.13966.

   ·  Cao, J., Ou, X., Zhu, D., Ma, G., Cheng, A., Wang, M., Chen, S., Jia, R., Liu, M., Sun, K. and Yang, Q., Wu, Y., Chen, X. The 2A2 protein of Duck hepatitis A virus type 1 induces apoptosis in primary cell culture. Virus genes, 2016. 52(6), pp.780-788.

   ·  Mao, S., Wang, M., Ou, X., Sun, D., Cheng, A., Zhu, D., Chen, S., Jia, R., Liu, M., Sun, K. and Yang, Q., Wu, Y., Zhao, X., Chen, X., Virologic and immunologic characteristics in mature ducks with acute duck hepatitis A virus 1 infection. Frontiers in immunology, 2017.8, p.1574.

   ·  Xie, J., Zeng, Q., Wang, M., Ou, X., Ma, Y., Cheng, A., Zhao, X.X., Liu, M., Zhu, D., Chen, S. Jia, R., Yang, Q., Wu, Y., Zhang, S., Liu, Y., Yu, Y., Zhang, L. and Chen, X. Transcriptomic characterization of a chicken embryo model infected with duck hepatitis A virus Type 1. Frontiers in immunology, 2018.9, p.1845.

   ·  Zhu, D., Chen, H., Ou, X., Liu, M., Wang, M., Zhao, X., Jia, R., Chen, S., Sun, K., Yang, Q. and Wu, Y., Chen, X. and Cheng, C., Comparison of immunohistochemistry and Ziehl‐Neelsen staining for detecting the distribution of Mycobacterium avium subsp avium in naturally infected domestic Pekin ducks (Anas platyrhynchos domestica). Veterinary medicine and science, 2020. 6(2), pp.242-247.

   ·  Zhu, D.K., Song, X.H., Wang, J.B., Zhou, W.S., Ou, X.M., Chen, H.X., Liu, M.F., Wang, M.S., Jia, R.Y., Chen, S. and Sun, K.F., 2016. Outbreak of avian tuberculosis in commercial domestic Pekin ducks (Anas platyrhynchos domestica). Avian Diseases, 60(3), pp.677-680.